Medical-grade polyurethane resin TPU
ChronoFlex™ / ChronoThane™
HydroThane™ /
HydroMed™
PolyBlend 1100™

ABOUT

Mitsubishi Chemical has a long track record of adoption of urethane resins for medical use.
We acquired AdvanSource Biomaterials Corporation in North America in 2020.
We supply urethane-based resins (various compounds and coatings) used in implants and catheter products.
Flexible customization is also possible to meet a wide range of mechanical properties and processing method needs.

FEAUTURE

Characteristics of medical-grade polyurethane resin (TPU)

Mitsubishi Chemical's urethane resins have high biocompatibility, allowing us to offer a wide range of materials tailored to various applications and required properties, such as implantation in the body and high sliding properties.

Furthermore, our products are manufactured and developed under ISO 13485 certification and comply with various biological safety assessments, including USP Class VI.

Please verify suitability for your intended use with the final product.

■ChronoFlex™ (Carbonate-based)

It has high chemical resistance and mechanical properties, and excellent long-term durability.

Main intended uses: Intra-implantable devices such as CV ports, implantable devices

Isocyanates: Aliphatic or aromatic

Hardness range: 75A to 75D

■HydroThane™ (Hydrophilic)

It offers excellent sliding properties and flexibility within the body (in water).

Main intended uses: Catheters and devices for implantation in the body for less than 30 days.

Isocyanates: Aliphatic or aromatic

Hardness range: 80A to 93A

■Polyblend 1100™

An ultra-flexible elastomer that cannot be achieved with thermoplastic polyurethane.

Main intended uses: Balloon catheters and devices for implantation in the body for less than 30 days.

Isocyanates: Aromatic compounds

Hardness range: 12A to 80A

■ChronoThane™ (Ether-based)

It exhibits excellent mechanical properties, including tensile elongation.

Main intended uses: Catheters and devices for implantation in the body for less than 30 days.

Isocyanates: Aliphatic or aromatic

Hardness range: 75A to 75D

■HydroMed™ (For coating purposes only)

This superhydrophilic urethane coating provides lubrication through its high water absorption properties.

Main intended use: Indwelling devices for less than 30 days

Isocyanates: Aliphatic compounds

Product lineup and physical properties table

Chrono Flex™ C

Chrono Flex™ AL

ChronoThan™P

ChronoThan™T

HydroThane™ AR

HydroThane™ AL

HydroMed™ AL

PolyBlend 1100™

Isocyanate type

aromatic

aliphatic

aromatic

aliphatic

aromatic

aliphatic

aliphatic

aromatic

Polyol type

Polycarbonate

Polycarbonate

ether

ether

ether

ether

ether

ether

Hardness range

75A-75D

75A-75D

75A-75D

75A-75D

80A-93D

80A-93D

-

-

contrast agent

✓

✓

✓

✓

✓

✓

✓

-

Biocompatibility
(Implants placed less than 30 days ago)

✓

✓

✓

✓

✓

✓

✓

✓

Biocompatibility
(Implants placed more than 30 days ago)

✓

✓

-

-

-

-

-

-

Biocompatibility Assessment

item

Test method

Chrono Flex™C

Chrono Students™  AL

ChronoThane™ P

ChronoThane™T

HydroThane™ AR

HydroThane™ AL 

HydroMed™ AL

PolyBlend 1100™

Cytotoxicity test: MEM Elution method

ISO10993-5

Compatibility

Compatibility

Compatibility

Compatibility

Compatibility

Compatibility

Compatibility

Compatibility

Systemic toxicity test

USP Class VI

Compatibility

Compatibility

Compatibility

Compatibility

Compatibility

Compatibility

‐

‐

Inflammation and skin sensitization

USP Class VI

Compatibility

Compatibility

Compatibility

Compatibility

Compatibility

Compatibility

‐

‐

Burial experiment

USP Class VI

Compatibility

Compatibility

Compatibility

Compatibility

Compatibility

Compatibility

‐

‐

Phthalate (DEHP) free

ー

✓

✓

✓

✓

✓

✓

✓

✓

Animal-derived ingredient (BSE/TSE) free

ー

✓

✓

✓

✓

✓

✓

✓

✓

For the export of chemical products, we will check the regulations of each country and then respond regarding whether or not we can provide them.
Please be sure to include information such as the exporting country.
Please note that for some products, we may not be able to offer or provide a different grade.

CASE

Application example

catheter

implants

CONTACT

Before you start worrying about selecting and developing resin materials
Please contact Mitsubishi Chemical.

Polymer Compounds Business Group Products
Useful resources are available here.

Please feel free to ask any questions.
Please contact us.

The above information is based on the latest available information as of the date of creation and may be revised in the future based on new information.

Furthermore, this information is provided as general technical information and reference material, and we do not guarantee the accuracy or completeness of the content.

Product performance and characteristics may vary depending on usage conditions, processing conditions, etc. The final decision regarding applicability and design is the customer's responsibility.

We will check the regulations of each country regarding the export of chemical products and then respond whether or not we can provide them. Please be sure to include information such as the exporting country.

Depending on the product, we may suggest a different grade or may not be able to provide the product at all.

Mitsubishi Chemical Corporation

Mitsubishi Chemical Corporation
Polymer Compounds Business Group

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